Drug overdose occurs when an individual ingests or is exposed to a quantity of a substance that exceeds the body’s ability to metabolize or eliminate it, leading to toxic effects. Overdoses can involve prescription medications, illicit drugs, or even over-the-counter substances. Symptoms vary widely depending on the drug involved but may include altered mental status, respiratory depression, seizures, cardiac arrhythmias, and coma. Prompt medical attention is crucial to prevent serious complications or death. Treatment may involve supportive measures such as airway management, administration of antidotes or reversal agents (e.g., naloxone for opioid overdoses), intravenous fluids, and monitoring of vital signs. Psychological support and counseling may also be necessary to address underlying issues contributing to substance misuse.